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Hiroyasu Sakai Selected Research

Insulin-Like Peptides

12/2021Exogenous insulin-like growth factor 1 attenuates cisplatin-induced muscle atrophy in mice.
3/2020Alpha-Glucosidase Inhibitor Voglibose Suppresses Azoxymethane-Induced Colonic Preneoplastic Lesions in Diabetic and Obese Mice.
3/2011Preventive effects of (-)-epigallocatechin gallate on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db Mice.
5/2010(-)-Epigallocatechin gallate inhibits growth and activation of the VEGF/VEGFR axis in human colorectal cancer cells.
12/2009(-)-Epigallocatechin gallate prevents carbon tetrachloride-induced rat hepatic fibrosis by inhibiting the expression of the PDGFRbeta and IGF-1R.
9/2008(-)-Epigallocatechin gallate suppresses azoxymethane-induced colonic premalignant lesions in male C57BL/KsJ-db/db mice.
4/2008EGCG inhibits activation of the insulin-like growth factor (IGF)/IGF-1 receptor axis in human hepatocellular carcinoma cells.

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Hiroyasu Sakai Research Topics

Disease

32Asthma (Bronchial Asthma)
03/2024 - 02/2004
26Neoplasms (Cancer)
07/2023 - 10/2009
26Inflammation (Inflammations)
12/2021 - 12/2005
24Carcinogenesis
12/2021 - 09/2008
20Respiratory Hypersensitivity
01/2023 - 12/2003
13Obesity
03/2020 - 09/2008
12Hepatocellular Carcinoma (Hepatoma)
01/2022 - 04/2008
11Muscular Atrophy (Muscle Atrophy)
01/2024 - 07/2014
8Colorectal Neoplasms (Colorectal Cancer)
12/2021 - 09/2008
7Body Weight (Weight, Body)
02/2017 - 09/2008
6Atrophy
07/2023 - 01/2019
6Liver Neoplasms (Liver Cancer)
09/2020 - 04/2008
5Fatty Liver
05/2023 - 01/2011
5Alcoholic Fatty Liver
05/2023 - 12/2015
5Colonic Neoplasms (Colon Cancer)
12/2020 - 07/2010
5Allergic Rhinitis
01/2011 - 05/2006
4Diarrhea
01/2023 - 01/2013
4Non-alcoholic Fatty Liver Disease
08/2017 - 04/2014
3Weight Loss (Weight Reduction)
01/2022 - 03/2016
3Contact Dermatitis (Eczema, Contact)
12/2019 - 08/2017
3Diabetes Mellitus
03/2016 - 09/2008
3Insulin Resistance
01/2016 - 02/2010
3Hyperalgesia
03/2015 - 06/2012
3Neuralgia (Stump Neuralgia)
04/2014 - 06/2012
3Liver Cirrhosis (Hepatic Cirrhosis)
12/2012 - 12/2009
3Aberrant Crypt Foci
05/2012 - 09/2008
3Nasal Obstruction
10/2010 - 07/2006
2Adenoma (Adenomas)
01/2022 - 03/2016
2Colitis
12/2021 - 01/2021
2Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
12/2021 - 09/2018
2Ichthyosis (Xeroderma)
01/2021 - 08/2019
2Infections
09/2020 - 09/2019
2Dermatitis
01/2018 - 08/2017
2Liver Diseases (Liver Disease)
09/2017 - 08/2015
2Metabolic Syndrome (Dysmetabolic Syndrome X)
08/2017 - 01/2016
2Hyperinsulinism (Hyperinsulinemia)
03/2016 - 01/2016
2Fibrosis (Cirrhosis)
08/2015 - 12/2009

Drug/Important Bio-Agent (IBA)

21AntigensIBA
10/2019 - 01/2005
18Proteins (Proteins, Gene)FDA Link
10/2022 - 02/2004
10Cisplatin (Platino)FDA LinkGeneric
01/2024 - 07/2014
9Messenger RNA (mRNA)IBA
01/2018 - 02/2004
8TeaIBA
01/2023 - 10/2009
8CytokinesIBA
10/2020 - 02/2004
7Diethylnitrosamine (N-Nitrosodiethylamine)IBA
01/2022 - 02/2010
7Insulin-Like PeptidesIBA
12/2021 - 04/2008
6Fluorouracil (Carac)FDA LinkGeneric
01/2017 - 01/2013
63,7,11,15- tetramethyl- 2,4,6,10,14- hexadecapentaenoic acidIBA
01/2016 - 11/2009
5AzoxymethaneIBA
09/2023 - 09/2008
5rhoA GTP-Binding ProteinIBA
01/2023 - 12/2003
5Interleukin-6 (Interleukin 6)IBA
06/2020 - 03/2010
5Drinking WaterIBA
03/2020 - 09/2008
5Phosphotransferases (Kinase)IBA
11/2017 - 10/2009
5Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2017 - 02/2004
5AdipokinesIBA
03/2016 - 07/2010
5epigallocatechin gallate (epigallocatechin-3-gallate)IBA
01/2016 - 10/2009
4UbiquitinIBA
05/2023 - 01/2020
4Retinoid X Receptors (Retinoid X Receptor)IBA
01/2022 - 01/2011
4Interleukin-13IBA
10/2020 - 02/2009
4rho-Associated KinasesIBA
06/2017 - 12/2008
4tyrosine receptor (receptor, tyrosine)IBA
03/2015 - 10/2009
3CarcinogensIBA
09/2023 - 03/2010
3PlatinumIBA
07/2023 - 07/2014
3CateninsIBA
01/2022 - 06/2011
3Aquaporins (Water Channels)IBA
01/2021 - 01/2013
3LigandsIBA
01/2021 - 10/2012
3Insulin (Novolin)FDA Link
03/2020 - 04/2008
3ChemokinesIBA
12/2019 - 03/2010
3LipidsIBA
01/2019 - 06/2011
3RetinoidsIBA
09/2017 - 11/2009
3Interleukin-17 (Interleukin 17)IBA
06/2017 - 01/2013
3Branched-Chain Amino AcidsIBA
01/2016 - 02/2010
3sphingosine 1-phosphate (sphingosine-1-phosphate)IBA
10/2010 - 01/2010
3GlucocorticoidsIBA
01/2010 - 04/2008
2Ligases (Synthetase)IBA
05/2023 - 01/2022
2Ubiquitinated ProteinsIBA
01/2022 - 01/2020
2Dextrans (Dextran)FDA Link
12/2021 - 03/2010
2sodium sulfate (sodium bisulfate)FDA LinkGeneric
12/2021 - 03/2010
2MicroRNAs (MicroRNA)IBA
10/2020 - 01/2017
2Cyclooxygenase 2 (Cyclooxygenase-2)IBA
06/2020 - 01/2018
2Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
06/2020 - 05/2006
2Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
01/2020 - 01/2019
26- ((4- ethylphenyl)methyl)- 3',4',5',6'- tetrahydro- 6'- (hydroxymethyl)spiro(isobenzofuran- 1(3H),2'- (2H)pyran)- 3',4',5'- triolIBA
12/2019 - 08/2017
2Streptozocin (Streptozotocin)FDA Link
08/2019 - 09/2017
2InflammasomesIBA
01/2019 - 01/2018
2Prostaglandin D2IBA
01/2019 - 01/2018
2HaptensIBA
01/2018 - 08/2017
2CurcuminIBA
08/2017 - 01/2012
2AntioxidantsIBA
03/2016 - 03/2015
2AdiponectinIBA
03/2016 - 06/2011
2Sodium Glutamate (Accent)IBA
03/2016 - 12/2015
2Norepinephrine (Noradrenaline)FDA LinkGeneric
03/2015 - 07/2006
2salicylhydroxamic acid (SHAM)IBA
04/2014 - 05/2013
2Serotonin (5 Hydroxytryptamine)IBA
12/2013 - 06/2012

Therapy/Procedure

17Chemoprevention
12/2021 - 04/2008
11Therapeutics
09/2020 - 02/2007
7Drug Therapy (Chemotherapy)
01/2022 - 12/2013
4Subcutaneous Injections
09/2017 - 07/2010
2Diet Therapy (Therapy, Diet)
12/2021 - 07/2014
2Intranasal Administration
01/2018 - 08/2010
2Ligation
03/2015 - 06/2012